contents
1.Future generation foodstuff --- CHAMPEX®
2.2.Relationship of odors with diseases
2.3.2.function2 Prevention of diseases through suppressive effect on toxic chemicals in the blood
2.3.3.function3 Prevention of diseases through reinforcement of the immune system
Future generation foodstuff --- CHAMPEX®
CHAMPEX® is a functional extract of a mushroom, Agaricus bisporus, which has worldwide dietary consumption.
While CHAMPEX® has been widely used in foods for the control of mouth, body and fecal odors, and improvement of bowel conditions, it is only relatively recently that we have become aware of the ability of CHAMPEX® to cleanse the blood.
The future generation foodstuff, which makes our bodies healthier ---- CHAMPEX®.
ABOUT CHAMPEX®
CHAMPEX® is a functional foodstuff extracted from a mushroom, Agaricus bisporus.
CHAMPEX® adds new value to ordinary foods. Given the worldwide dietary consumption of Agaricus bisporus, there should be no doubt as to its safety for daily consumption.
Taking note of the mushroom's natural deodorizing properties, in 1987 we initiated research into extracting the active ingredients from greenhouse-grown mushrooms (Agaricus bisporus). In the course of our research, we discovered that CHAMPEX® also has the ability to cleanse the human blood. This cleansing function is considered beneficial for numerous practical applications, such as activating the immune system, inhibiting the growth of H. pylori, arresting the progress of chronic renal failure and reducing active oxygen.
CHAMPEX® is currently used in a wide range of candies, jellies, beverages and health diets for hospital use. It is being adopted for a growing array of new applications, including foods for specific health purposes.
A portion of the foods we ingest is decomposed and converted by intestinal bacteria into toxic chemicals such as ammonia, indole, skatole, tryptamine, mercaptans, hydrogen sulfide and amines. These products can cause fecal, mouth and body odors. Furthermore, these toxic by products can cause various problems such as diseases and aging.
< Diseases caused by intestinal putrid products >
| Intestinal putrid products | Exposure limit (ppm) | Concentration in feces (ppm,average of the aged) | Diseases |
|---|---|---|---|
| ammonia | 25ppm | 70ppm | hepatic encephalopathy, nausea, fever |
| amines | 25ppm | 10ppm | inflammation, hypertension, cancer |
| mercaptans | 0.5ppm | 60ppm | anemia, fever, coma, cerebral disorders |
| hydrogen sulfide | 10ppm | 12ppm | hypotension, nausea, loss of appetite |
| indole skatole tryptamine | - | - | cancer, leukemia |
A portion of the foods we ingest is decomposed and converted by intestinal bacteria into toxic chemicals such as ammonia, mercaptans, indole, hydrogen sulfide. These by products are not only offensive but also harmful substances with high toxicity. It is known that these products cause renal failure, liver disease, hypertension, cancer and other diseases. CHAMPEX® is able to suppress these products. In addition, CHAMPEX® has various functions that help our bodies become healthier, suppress putrid chemicals and control mouth and body odors.
1) Control of putrid substances
Consumed orally, CHAMPEX® reacts with putrid substances in the intestines. CHAMPEX® was administrated to eight volunteers using a daily dose of 500 to 1,500 mg. The concentration of ammonia and sulfides were determined using ammonium and sulfide electrodes, respectively. Indole, skatole and phenol values were determined using gas chromatography.
As shown in the figures below, typical putrid substances decreased by 40 to 60% after ingestion of CHAMPEX® for 14 days, compared with odors before the CHAMPEX® regimen.
2) Suppressive effect on foul breath
Methylmercaptan concentration measured using GC method,
CHAMPEX® was accurately weighed in amounts of 2, 5 and 10mg. Each quantity was then dissolved in 3ml of distilled water. Immediately after, each solution was poured into a 125ml vial, then standard methylmercaptan was injected into the vial to obtain a 0.5ppm solution. Using CHAMPEX® at 2mg and 5mg, the methylmercaptan disappeared completely after 45 minutes and 15 minutes, respectively.
Organoleptic test of mouth odors:
An organoleptic test was conducted, involving 63 female college students. Following a meal of garlic-seasoned barbecued meats, each participant took a candy containing 0.125% CHAMPEX®. Fifty-eight of the 63 participants (92%) responded that CHAMPEX® was effective in eliminating mouth odors.
3) Suppressive effect on fecal odors
Following operations for colon cancer, nine patients ingested five CHAMPEX® tablets (BX100FPD-S 500mg/day) for 30 day. The intensity of fecal odors was compared before and after ingestion. Compared with an odor intensity of 100% prior to ingestion, foul odors decreased to 43% after 10 days of using CHAMPEX® and 29% after 20 days.
Blood purification
One of the toxic chemicals in your blood, ammonia, is known to cause hepatic encephalopathy, paralyzing cranial nerves if the ammonia blood level increases excessively.
Blood ammonia levels were measured after CHAMPEX® jelly was given to 14 elderly inpatients for 30 days. Ammonia levels began to fall after 10 days, and fell off remarkably after 30 days.
1) Activation of the immune system
Natural killer cells are an important first line of defense against newly arising malignant cells and cells infected with viruses, bacteria, or protozoa. Medical research has shown that low NK cell activity is present in most morbid conditions. After oral ingestion of CHAMPEX® to 14 patients, at 400mg for 30 days, NK cell activity had substantially increased. CHAMPEX® was proven to be highly effective in increasing the activity of NK cells.
2) Increase of Bifidobacteria with decrease in Clostridia
Maintaining a dominant balance of Bifidobacterium in the enteric bacterial flora is recognized as an important step for protection against cancers, arteriosclerosis and other elderly diseases. CHAMPEX® (BX100FPD-S) was ingested by eight volunteers using a daily dose of 500 to 1,500 mg and the fecal bacteria populations were examined. The results indicated a substantial increase in the Bifidobacterium population while Clostridia populations decreased significantly.
3) Control of progressive renal failure
As chronic renal failure advances, the levels of both creatinine clearance (Ccr) and reciprocal of serum creatine (Scr-1) decrease. Continuous ingestion of CHAMPEX® (BX100FPD-S 2,000mg/day) for more than 3 months improves these indexes and arrests the progress of chronic renal failure.
4) Elimination of oxygen radicals
Excess oxygen radicals may lead to cancer or arteriosclerosis. In vitro experiment shows that a low concentration (10µg/ml) of CHAMPEX® effectively decreases oxygen radicals by approximately 50%.
5) Suppression of leucotriene
Leucotriene is a major substance of direct allergens for asthma. Low concentrations (10µg/ml) of CHAMPEX® inhibits in vitro the generation of leucotriene by approximately 50%.
6) Prevention of gout
Increased uric acid in the blood causes gout, which is accompanied by severe pain. If it increases excessively, it causes vascular disorders in the brain and heart, and urinary calculus. In vivo experiments indicate that a regimen of CHAMPEX® (BX100FPD-S 100mg/kg) is effective in decreasing the blood level of uric acid by 35%.
7) Growth inhibition of H. pylori
Helicobacter pylori appears to be the origin of intestinal ulcers and stomach cancer.
A 40 to 80 dilution of CHAMPEX® (BX100) is effective in suppressing the growth of various clinically isolated strains of Helicobacter pylori.
| Strains of H. pylori | Growth inhibition | |
| Dilution | ||
| 40 | 80 | |
| ATCC43526 ATCC43629 ATCC43579 | x x x | - - x |
| Clinical strain1 Clinical strain2 | x x | - - |
| Clinical strain3 Clinical strain4 | x x | x x |
- not inhibited
Prevention of aging
Excessive oxygen radicals may lead to cancer or arteriosclerosis. In vitro experiments show that a low concentration (10µg/ml) of CHAMPEX® effectively decreases oxygen radicals by approximately 50%.
CHAMPEX® is available to food manufacturers only, as a raw material.
Consumers can purchase products containing CHAMPEX®, being sold in retailers.
| Product: | CHAMPEX® (BX100FPD-S, BX150FPD-S) |
| Raw material: | Agaricus bisporus (a mushroom) |
| Safety: | Safety of CHAMPEX® has been proven and confirmed in tests for acute and sub acute oral toxicity and reverse mutation, conducted by an official organization. |
Manufacturing process:
Chemical properties:
| Description | Brown powder with distinctive odor and acidic taste. |
| Deterioration | Remains stable for 3 years when stored at ambient temperatures in a tightly sealed container. As CHAMPEX® is a natural product, precipitates may occur, but there will be no change in the deodorizing effect whether filtrated or not. |
| Light stability | Product color may darken slightly after exposure to light, but the change is not significant. |
| Solubility | 1)Water Solubility is accelerated when the water temperature is high. CHAMPEX® is easily soluble when added to a solvent. CHAMPEX® dissolves easily with intense stirring. 2)To increase CHAMPEX® solubility, dissolve it in a solvent at raised temperatures. Add CHAMPEX® to the solvent little by little. Mix CHAMPEX® with other ingredients (sugar, amino acid, etc) prior to dissolving it in a solvent. 3)CHAMPEX® is not soluble in oil. The standard proportion for adding CHAMPEX® to oil in a soft capsule is about 30%. |
| Mixing compatibility | CHAMPEX® is compatible with natural fruit juice, such as apple, prune, peach and orange juice, and carbonated water. It is also compatible with all vitamins. CHAMPEX® can be mixed with virtually any foodstuff. |
| Thermal resistance | No change in deodorizing properties in 5-minute boiling tests at 180°C. |
| Acid resistance | No change in deodorizing properties in strong acid conditions. |
| Alkali resistance | No change in deodorizing properties at up to pH 10. |
| Product category | CHAMPEX® is not a food additive. It is a food. |
| Batch stability | Assay results with 100 batches indicate no discrepancy between specifications and actual measured values. |
CORPORATE PROFILE
RICOM CORPORATION
| Address | TOMIN-KOGYO IKEBUKURO BLDG, 7F, 2-26-5, Minami-ikebukuro, Toshima-ku, Tokyo 171-0022 JAPAN |
| President | Tadao Hamaya |
| Established | September 1982 |
| Business line | Development and marketing of functional foodstuff |
| Number of employees | 26 (as of January, 2002) |
| Capital | 18 million yen |
| Main customers | Ajinomoto Takara Corporation, Aliment Industry Co.,Ltd., ITOHAM FOODS Inc, Kongo Yakuhin Co.,Ltd., SHIN-SHIN KAKEN CO.,LTD., SHIN MITSUI SUGER CO.,LTD., SHINRAI CHEMICAL CO.,LTD., ZERIA Pharmaceutical Co.,Ltd., TSUKUBA DAIRY PRODUCTS CO.,LTD., TRADEPIA CORPORATION, NICHIYU TRADING CO.,LTD., Hanwa-sangyo Co.,Ltd., FANCL CORPORATION, Health Way CO.,LTD, MITSUI & CO.,LTD, MEIJI DAIRIES CORPORATION, Yuuki system Corporation, etc |
CHAMPEX® is a functional foodstuff, made from the extract of a mushroom, Agaricus bisporus, which has worldwide dietary consumption. With this epoch-making functional foodstuff, made from a familiar food, the market of CHAMPEX® is now spreading over the world.
Patents)
1. European Patent No.0381055 (England, France, Germany, Switzerland, Spain & Sweden)
2. USA Patent No.5,639,470
3. USA Patent No.5,804,174
4. Korean Patent No.193292
5. Japanese Patent No.2930323
6. Canadian Patent No.2,008,344
Trade Marks)
Japan : Class 29 & Class 32
CHAMPEX®
USA : Class 5
CTM Europe : Class 5 & 30
CTM (15 European) countries : Austria, Belgium, Denmark, Finland, France, Germany, England, Greece, Ireland, Italy, Luxembourg, Holland, Portugal, Spain, and Sweden
Thailand : Class 29
CHAMPEX® logo designed by Mr. Tatsuya Ishii
The CHAMPEX® logo was designed by Tetsuya Ishii, celebrated designer and ex-member of musical group Club KOME-KOME, to visually represent its functions.
The central character shows a mushroom, the source of CHAMPEX®. The horizontal background lines suggest the influence of CHAMPEX® in eliminating odors from the digestive organs.
